Clinical Efficacy

Proven Clinical Results – Unique Study Design

  • Fully blinded with sham device (Placebo) as control arm
  • Eliminated Placebo Effect – Patients and Clinicians did not know treatment arm
  • Highest Level of Clinical Evidence – Level 1A (Double Blind with Placebo)
eo2 levels of evidence

Statistically Significant Outcomes in 12 Weeks

  • CDO leads to significantly higher rates of closure (2x to 3x)
  • CDO works better in more chronic wounds (lower PWAR*)
  • CDO resulted in significantly faster time to closure (P<0.001)
eo2 closure rate

How Oxygen Works In Wound Healing

Increases Cell Metabolism & Energy
Continuous Pure Oxygen boosts vitality 7

Enhances Bodies Own Anti-Bacterial Capacity
Create Reactive Oxygen Species (i.e. Hydrogen Peroxide) 5,6

Greater Wound Profusion
Rate of angiogenesis proportional to oxygen concentration 8,9
Better Strength & Appearance
  • Higher tensile strength (reduced recurrence) 10,11
  • Better collagen organization (reduced scarring) 12
Faster Cell Growth & Re-epithelialization
  • Increased collagen deposition (faster repair) 11,13,14
  • Up to 70% faster endothelial gap closure rate 12
Read More about how oxygen works in wound healing

Publications

A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Sham Therapy in the Treatment of Diabetic Foot Ulcers

A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Sham Therapy in the Treatment of Diabetic Foot Ulcers

Mark Q. Niederauer, PhD1, Joel E. Michalek, PhD2, and David G. Armstrong, DPM, MD, PhD3 Abstract Background: Over the past…

Does Continuous Diffusion Of Oxygen Have Potential In Chronic Diabetic Foot Ulcers?

Does Continuous Diffusion Of Oxygen Have Potential In Chronic Diabetic Foot Ulcers?

Mark Couture, DPM, Central Texas Veteran’s Healthcare Administration, Temple, TX Chronic wounds, typically defined as wounds that have not decreased…

Can Continuous Diffusion of Oxygen Heal Chronic Toe Ulcers?

Can Continuous Diffusion of Oxygen Heal Chronic Toe Ulcers?

Gabriel Urrea-Botero, MD, Wound Care Specialist at Gonzaba Medical Group, San Antonio, TX When other modalities fail to heal chronic…

Treatment of a Venous Leg Ulcer using TransCu O2

Treatment of a Venous Leg Ulcer using TransCu O2

Stephanie Wu, DPM, MSc, Chicago Illionis Patient: 53 year old female Wound History: Duration of ulcer prior to treatment with CDO…

Case Studies

eo2 case studyOutcome: Wound Closed
Days on Service: 47

eo2 case studyOutcome: Wound Healed
Days on Service: 81

eo2 case studyOutcome: Wound healed
Days on Service: 55

eo2 case studyOutcome: 99% Closure
Days on Service: 93

EO2 Concepts® is an ISO 13485:2003 certified company that maintains European Commission CE mark certification and obtained its Canadian Medical Device License for distribution of innovative wound care products throughout the United States, Canada and the European Union.

iso certification

ce mark

cmdcas

canadian medical license

iso certificationce markcmdcascanadian medical license