Clinical Efficacy

Proven Clinical Results – Unique Study Design

  • Fully blinded with sham device (Placebo) as control arm
  • Eliminated Placebo Effect – Patients and Clinicians did not know treatment arm
  • Highest Level of Clinical Evidence – Level 1A (Double Blind with Placebo)
eo2 levels of evidence

Statistically Significant Outcomes in 12 Weeks

  • CDO leads to significantly higher rates of closure (2x to 4.6x)
  • CDO works better in more chronic, larger and weight-bearing wounds
  • CDO resulted in significantly faster time to closure (P<0.001)
  • Debridement significantly improves CDO outcomes
eo2 closure rate

 Sources: • Centre for Evidence Based Medicine, cebm.net • Journal of Pharmacology (2013, 4:2,pp 88-169) • Center for Evidence Based Management, cebma.org  

How Oxygen Works In Wound Healing

Increases Cell Metabolism & Energy
Continuous Pure Oxygen boosts vitality to support increased demand during healing 2-16

Faster Cell Growth & Wound Closure
  • Increased collagen deposition (faster repair) 17-29,59
  • Up to 70% faster endothelial gap closure rate
Rapid Pain Relief
  • Over half of patients experience >75% reduction within 4 days 28-32
  • Significant pain relief in a variety of wounds
Greater Wound Perfusion
Rate of angiogenesis proportional to oxygen concentration 33-40
Enhances Bodies Own Anti-Bacterial Capacity
Create Reactive Oxygen Species (i.e. Hydrogen Peroxide) 19,41-49,51

Better Strength & Appearance
  • Higher tensile strength (reduced recurrence) 50-61
  • Better collagen organization (reduced scarring)
Read more about How Oxygen Works In Wound Healing

Publications


Level of Evidence Author (s) Study Year Published Publication Site Wound Type Citation
1C Lavery LA, Killeen AL, Farrar D, Akgul Y, Crisologo PA, Malone M, Davis KE The Effect of Continuous Diffusion of Oxygen Treatment on Cytokines, Perfusion, Bacterial Load, and Healing in Patients with Diabetic Foot Ulcers 2020 International Wound Journal Various Lavery LA, Killeen AL, Farrar D, Akgul Y, Crisologo PA, Malone M, Davis KE. The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers. Int Wound J. 2020;1–10. View Site https://doi.org/10.1111/iwj.13490
1C Chan BCF, Campbell, KE An Economic Evaluation Examining the Cost‐effectiveness of Continuous Diffusion of Oxygen Therapy for Individuals with Diabetic Foot Ulcers 2020 International Wound Journal DFU Chan BCF, Campbell, KE, An economic evaluation examining the cost‐effectiveness of continuous diffusion of oxygen therapy for individuals with diabetic foot ulcers. Int Wound J. 2020;1–18. View Site https://doi.org/10.1111/iwj.13468
4A Kimmel HM A Comparison of Continuous Oxygen Therapy to Topical Oxygen 2019 Foot & Ankle Quarterly Various Kimmel HM, A Comparison of Continuous Oxygen Therapy to Topical Oxygen, Foot & Ankle Quarterly, Winter 2019, 30(4) 203-209
1A Lavery LA, Niederauer MQ, Papas KK, Armstrong DG Does Debridement Improve Clinical Outcoes in People with DFU Ulcers Treated with CDO? 2019 Wounds DFU Lavery LA, Niederauer MQ, Papas KK, Armstrong DG, Does Debridement Improve Clinical Outcomes in People with DFU Ulcers Treated with CDO? Wounds 31(10):246-251 2019. Epub 2019 July 31.
1A Niederauer MQ, Michalek JE, Liu Q, Papas, Lavery LA, Armstrong DG Continuous Diffusion of Oxygen Improves Diabetic Foot Ulcer Healing When Compared with a Placebo Control: a Randomised, double-blind, multicentre study 2018 Journal of Wound Care DFU Niederauer MQ, Michalek JE, Liu Q, Papas, Lavery LA, Armstrong DG. Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control: a randomised, double-blind, multicentre study. J Wound Care 27(9):s30-s45 2018.
2A Bowen J, Ingersoll MS, Carlson R Effect of CDO on Pain in Treatment of Chronic Wounds 2018 Wound Central Various Bowen J, Ingersoll MS, Carlson R. Effect of CDO on Pain in Treatment of Chronic Wounds. Wound Central 2(4);186-195 2018.
1A Niederauer MQ, Michalek JE, Armstrong DG A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Sham Therapy in the Treatment of Diabetic Foot Ulcers 2017 Journal of Diabetes Science & Technology DFU Niederauer MQ, Michalek JE, Armstrong DG. A Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Sham Therapy in the Treatment of Diabetic Foot Ulcers. J Diabetes Science Tech. 2017, Special Issue, 1-9. DOI: 1h0t.t1p1s:7//7d/o1i.9o3rg2/1209.6118717/1693525279468
1A Niederauer MQ, Michalek JE, Armstrong DG Interim Results for a Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Standard Moist Wound Therapy in the Treatment of Diabetic Foot Ulcers. 2015 Wound Medicine DFU Niederauer MQ, Michalek JE, Armstrong DG. Interim Results for a Prospective, Randomized, Double-Blind Multicenter Study Comparing Continuous Diffusion of Oxygen Therapy to Standard Moist Wound Therapy in the Treatment of Diabetic Foot Ulcers. Wound Medicine 8:19-23, 2015.
2A Couture M Does Continuous Diffusion of Oxygen Have Potential in Chronic Diabetic Foot Ulcers? 2015 Podiatry Today DFU Couture M. Does Continuous Diffusion Of Oxygen Have Potential In Chronic Diabetic Foot Ulcers? Podiatry Today 28(12) 2015.
2A Urrea-Botero G Can Continuous Diffusion of Oxygen Heal Chronic Toe Ulcers? 2015 Podiatry Today Toe Ulcers Urrea-Botero G. Can Continuous Diffusion of Oxygen Heal Chronic Toe Ulcers? Podiatry Today 28(10) 2015.
3B Brannick B, Engelthaler M, Jadzak J, Wu S A Closer Look at Continuous Diffusion of Oxygen Therapy for a Chronic, Painful Venous Leg Ulcer 2014 Podiatry Today Various Brannick B, Engelthaler M, Jadzak J, Wu S. A Closer Look at Continuous Diffusion of Oxygen Therapy for a Chronic, Painful Venous Leg Ulcer. Podiatry Today 27(11) 2014.
4A Howard MA, Asmis R, Evans KK, Mustoe TA Oxygen and Wound Care- A Review of Current Therapeutic Modalities and Future Direction 2013 Wound Repair and Regeneration Various Howard MA, Asmis R, Evans KK, Mustoe TA. Oxygen and wound care- A review of current therapeutic modalities and future direction. Wound Rep Reg. 2013; 21(4):503-511.
4B Asmis R, Qiao M, Zhao Q Low-Flow Oxygenation of Full-Excisional Skin Wounds on Diabetic Mice Improves Wound Healing by Accelerating Wound Closure and Reepithelialization 2010 International Wound Journal Preclinical Asmis R, Qiao M, Zhao Q. Low-Flow Oxygenation of Full-Excisional Skin Wounds on Diabetic Mice Improves Wound Healing by Accelerating Wound Closure and Reepithelialization. Int Wound J 2010 ; 7: 349-357.
3B Various Case Reports on Variety of Wounds Various eo2.com Various N/A

Case Studies

eo2 case studyOutcome: Wound Closed
Days on Service: 47

eo2 case studyOutcome: Wound Healed
Days on Service: 81

eo2 case studyOutcome: Wound healed
Days on Service: 55

eo2 case studyOutcome: 99% Closure
Days on Service: 93

EO2 Concepts® is an ISO 13485:2016 certified company that maintains European Commission CE mark certification and obtained its Canadian Medical Device License for distribution of innovative wound care products throughout the United States, Canada and the European Union.

cmdcas

canadian medical license